7.02.2016

L-Cysteine is the worlds best natural chelator vs DMPS and DMSA for chelation

Here we are going to learn about chelation.

"The sulfhydryl group (-SH), also called a thiol, is indicated in chemistry nomenclature by "-thiol" as a suffix and "mercapto-" or "sulfanyl" as a prefix. Thiols have great affinity for soft metals"

[[So the thiol group is like a magnet for mercury.]]



Water solubility:

A sulfonate group group is (-SO3) "sulfonates often used as fuel oil additives. They are completely oil soluable with good stability in the presence of water."  So they are not water soluble.


An acetate group (-COOH) is quite water soluble:
Magnesium Acetate 56.7g/100mL (0 °C)

[[So an acetate group is a good group to increase a molecules water solubility]]



"Most primary amines (-NH2) are good ligands for metal ions to give coordination complexes."

[[So the amine group is clamp for mercury]]



More info if you're curious:
[["a ligand[help 1] is an ion or molecule(functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electron pairs.

In chemistry, a coordination complex or metal complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.[1][2]"]]

So if we were to build a chelator given what we know what would we do?  How about start with a carboxylate group, add an amine group as a mercury clamp, and add a sulfahydryl group as a mercury magnet?  Good thinking, yes.

So now lets look at some "chelators" and apply our principles.


sulfonate (so3) group makes this one very low water solubility so it cannot be absorbed through the gut.  Also 2 sulfhydryl groups make this one kind of wonky, it won't be able to figure out which group to have attach to the mercury.  A lack of an amine group makes it so this molecule can "loose it's grip" on mercury kind of like the wimpy "claw" at a carnival game.  

Alright good, lets look at this one:

Well this one has dual carboxyl groups so it is very water soluble.  But this also makes it easy to get a hold of for microbes and therefore labile to microbial digestion in the gut.  Also the sulfhydryl groups in the center don't have good access to get at the mercury.  And this one looks like it could very easily loose its grip on the mercury.  This one would more likely try to push mercury around instead of remove it from the body.

Alright and finally this one:


This one has a carboxyl group for good water solubility, has a NH2 group as a metal ion ligand to hold on to the metal ion, and a sulfahydryl group (-SH) that acts as a magnet.  This one has everything we are looking for, no more no less.  Quite elegant and sexy.

Alright now of all three of these common chelating agents 1 is made by nature and 2 are made by dumbass humans.  Can you guess which are which? Yup you guessed it, the first one is the pharmecutical DMPS, the second one is DMSA, and the third one is good ol' L-Cysteine (Not n-acetyl cysteine which is messed up).

Yes ladies and gentlemen the last chelator is made by nature and is cheap and widely available, and no prescription is needed.  Are you even surprised though?  L-Cystiene is the worlds perfect mercury and heavy metal chelator.  Treasonous people sell out their fellow humans to get a patent and make a buck on selling drugs.  And they produce utter shit as expected from people who hate their species.

1 comment:

  1. What's the best way to increase Cysteine in diet?

    ReplyDelete

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